Aakash Manthan Industries
S8- Sarifa Mansion, 2nd Flank Road, Chinchbunder, Opp. Kesar Baug, Mumbai 400009. India
Tele: 91-22-23770100; Fax: 91-22-23728264; Mobile: 91-9821870100; e-mail: info@mubychem.com

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Hyaluronic Acid & Sodium Hyaluronate BP Ph Eur USP NF Grade Manufacturers

SDS of Hyaluronic Acid

SDS of Sodium Hyaluronate

Hyaluronic Acid also known as hyaluronan or hyaluronate, is a carbohydrate, more specifically a mucopolysaccharide occurring naturally throughout the human body.

Specifications of Hyaluronic Acid:
CAS Number: 9004-61-9
Appearance: White powder
Mesh I00% pass through: All passes 80 mesh
Hyaluronic Acid: 95.0 % 99%
Molecular weight (1.0-1.5) x 1000000
Glucuronic acid: 45.0% to 47%
Loss on drying: Maximum 10%
pH(0.1%Solution): 6.0-7.5
Transparency (0.1 % solution): >99. to 99.5%
Proteins (drv basis): Maximum 0.l%
Residue on ignition: Maximum 20%
Heavy Metals: Maximum 20ppm
Arsenic: Maximum 2ppm
Total Plate Count: Maximum 100cfu/gm
Yeast and molds: Maximum 10cfu/gm
Staphylococcus aureus: Negative
Pseudomonas aeruqinosa: Negative.

Sodium hyaluronate is the sodium salt of hyaluronic acid. It is a glycosaminoglycan and long-chain polymer of disaccharide units of Na-glucuronate-N-acetylglucosamine. Sodium hyaluronate is similar to the fluid that surrounds the joints in your body. This fluid acts as a lubricant and shock absorber for the joints. Sodium hyaluronate is used to treat knee pain caused by osteoarthritis.

Sodium Hyaluronate BP Grade
Ph Eur monograph
(C14H20NNaO11)n ---
CAS 9067-32-7
Action and use: High viscosity mucopolysaccharide.

DEFINITION
Sodium salt of hyaluronic acid, a glycosaminoglycan consisting of D-glucuronic acid and Nacetyl- D-glucosamine disaccharide units.
Content: 95.0 per cent to 105.0 per cent (dried substance).
Intrinsic viscosity: 90 per cent to 120 per cent of the value stated on the label.

PRODUCTION
It is extracted from cocks' combs or obtained by fermentation from Streptococci, Lancefield Groups A and C. When produced by fermentation of gram-positive bacteria, the process must be shown to reduce or eliminate pyrogenic or inflammatory components of the cell wall.

CHARACTERS
Appearance: White or almost white, very hygroscopic powder or fibrous aggregate.
Solubility: Sparingly soluble or soluble in water, practically insoluble in acetone and in anhydrous ethanol.

IDENTIFICATION
A. Infrared absorption spectrophotometry. ComparisonıPh. Eur. reference spectrum of sodium hyaluronate.
B. It gives reaction of sodium.
TESTS
Solution S: Weigh a quantity of the substance to be examined equivalent to 0.10 g of the dried substance and add 30.0 ml of a 9 g/l solution of sodium chloride. Mix gently on a shaker until dissolved (about 12 h).
Appearance of solution: Solution S is clear and its absorbance at 600 nm is not greater than 0.01.
pH: 5.0 to 8.5.
Dissolve the substance to be examined in carbon dioxide-free water to obtain a solution containing a quantity equivalent to 5 mg of the dried substance per millilitre.
Intrinsic viscosity: To pass the test.
Sulphated glycosaminoglycans: Maximum 1 per cent, if the product is extracted from cocks' combs.
Nucleic acids: The absorbance of solution S at 260 nm is maximum 0.5.
Protein: Maximum 0.3 per cent; maximum 0.1 per cent, if intended for use in the manufacture of parenteral preparations.
Chlorides: Maximum 0.5 per cent.
Iron: Maximum 80.0 ppm.
Heavy metals: Maximum 20 ppm; maximum 10 ppm if intended for use in the manufacture of parenteral preparations.
Loss on drying: Maximum 20.0 per cent, determined on 0.500 g by drying at 100-110C over diphosphorus pentoxide for 6 h.
Microbial contamination: Total viable aerobic count not more than 100 micro-organisms per gram. Use 1 g of the substance to be examined.
Bacterial endotoxins: Less than 0.5 IU/mg, if intended for use in the manufacture of parenteral preparations without a further appropriate procedure for the removal of bacterial endotoxins; less than 0.05 IU/mg, if intended for use in the manufacture of intra-ocular preparations or intra-articular preparations without a further appropriate procedure for the removal of bacterial endotoxins.

Sodium Hyaluronate USP NF Grade can also be offered.

Aakash Manthan Industries and the group companies are manufacturing chlorides since several decades. We have automatic vacuum operated titanium evaporators and SS316 equipments to produce top grade of chemicals. We have toll manufacturers and representatives in China, UAE, Europe, Canada & USA and agents & customers in all countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Bangkok Thailand, Malaysia, Dubai UAE etc. & sales representative in Chicago, Houston New York & Los Angeles, USA. Associated units are FDA-GMP-GLP certified, Halal and/or Kosher certified, REACH registered, ISO-9001, ISO-22000 HACCP certified.

Contact Hyaluronic Acid & Sodium Hyaluronate BP Ph Eur USP NF Grade manufacturers exporters:

Aakash Manthan Industries
S-8, SARIFA MANSION, 2ND FLANK ROAD, CHINCHBUNDER, MUMBAI 400009, INDIA
TEL: (OFFICE) 91-22-23770100, 23726950, 23774610, 23723564. FAX: 91-22-23728264

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